At Poltava, Ukraine:
Dino Peric scored the winning goal in the 64th minute as Lokomotiva Zagreb held off Vorskla Poltava 3-2 on the road in game two, and by that same score on aggregate, won their series with the Ukrainian club and advanced to the playoff round.
At Athens, Greece:
Robert Beric scored the only goal of both the game and the series in the 23rd minute as Saint-Etienne knocked off AEK Athens 1-0 on the road in game two, and by that same score, advanced to the playoff round.
Ivan Trickovski scored the only goal of the match in the 89th minute as AEK Larnaca defeated Spartak Moscow 1-0 on the road in game two and ousted the Russian club 2-1 on aggregate.
At Netanya, Israel:
With Nosa Igiebor (24') and Ezequiel Scarione (80') each scoring once, Maccabi Tel Aviv defeated visiting Pandurii Targu Jiu 2-1 in game two and won their series 5-2 on aggregate.
At Brest, Belarus:
Sinisa Babic (32') and Nokola Antic (81') delivered the scoring as Vojvodina knocked off Dinamo Minsk 2-0 on the road in game two and took their series 3-1 on aggregate.
At Haderslev, Denmark:
Marc Pedersen scored in the 65th minute as SonderjyskE gained a 1-1 game-two home draw with Zaglebie Lubin and took out the Polish club 3-2 on aggregate.
At Reggio Emilia, Italy:
Domenico Berardi scored twice (19', PK-39') as Sassuolo dominated visiting FC Lucerne 3-0 in game two and finished off the Swiss club 4-1 on aggregate.
At Vila do Conde, Portugal:
Josef Husbauer's goal in the 23rd minute carried Slavia Prague to a game-two 1-1 road draw with Rio Ave, lifting the Czech club into the playoff round thanks to the away-goals rule (1-1 on aggregate).
At Krasnodar, Russia:
Kouassi Eboue (15'), Joaozinho (37'), and Ricardo Laborde (38') produced the goals as FC Krasnodar defeated visiting Birkirkara 3-1 as the Russian club dispatched the Maltese club 6-1 on aggregate.
At Peristeri, Greece:
Dabney dos Santos (29') and Derrick Luckassen (36') each scored once as AZ Alkmaar defeated PAS Giannina 2-1 on the road in game two and won their series 3-1 on aggregate.
At Jerusalem, Israel:
Omer Atzili (PK-16'), Itay Shechter (29'), and Marcel Heister (47') each tallied once as Beitar Jerusalem dominated visiting Jelgava 3-0 in game two and won their series with the Latvian club 4-1 on aggregate.
At Trnava, Slovakia:
It was a big day for Kevin Friesenbichter. His goal in the 88th minute of regulation enabled Austria Vienna to take the second game of their series with Spartak Trnava 1-0 on the road, thus deadlocking the series at 1-1 on aggregate. After 30 minutes of scoreless overtime, it was Kevin who delivered the game-winning spot kick as the Austrian club won the penalty-kick shootout 5-4 to advance to the second round. Jens Larsen, Ismael Tajouri, Marko Kvasina, and Tarken Serbest also converted their PKs in the shootout for the Violets.
At Stockholm, Sweden:
Victor Ibarbo (46') and Marcus Berg (73') each delivered a goal as Panathinaikos blanked AIK Solna 2- on the road in game two and took out the Swedish club 3-0 on aggregate.
At Tallinn, Estonia:
Numan Curuksu (4') and Dzon Delarge (29') each scored once as Osmanlispor blanked Nomme Kalju 2-0 on the road in game two and won their series 3-0 on aggregate.
At Maribor, Slovenia:
Graeme Shinnie's own goal in the fourth minute of second-half stoppage proved fatal to Aberdeen as Maribor took game two 1-0 at home and eliminated the Scottish club 2-1 on aggregate.
At Baku, Azerbaijan:
Filip Ozobic scored the only goal of the match in the 34th minute as Gabala defeated visiting LOSC Lille Metropole 1-0 in game two and ousted the Mastiffs 2-1 on aggregate.
At Split, Croatia:
Tino Susic scored twice (PK-52', 56') as Hajduk Split defeated visiting FC Oleksandria 3-1 in game two and won their series 6-1 on aggregate.
At Brondby, Denmark:
Teemu Pukki produced a hat trick (3', 34', 52') as Brondby overcame their series-opening defeat in the German capital with a 3-1 game-two home win over Hertha Berlin and won their series 3-2 on aggregate.
At Rijeka, Croatia:
Edin Visca scored twice (43', 74') as Istanbul Basaksehir gained a 2-2 game-two road draw with Rijeka, good enough for the Turkish club to advance to the playoff round on away goals (2-2 on aggregate).
At Arouca, Portugal:
Despite being held to a 0-0 game-two home draw with Heracles Almelo, Arouca, with the aggregate score at 1-1, still advanced on away goals.
At Vienna, Austria:
Mario Pavelic (26'), Thomas Schrammel (36'), and Louis Schaub (90'+2) each scored once as Rapid Vienna dominated visiting Torpedo Zhodino 3-0 in game two and eliminated the Belarusian club by that very same score on aggregate.
At Cork, Ireland:
Thomas Buffel (12') and Sebastien Dewaest (41') each scored once as KRC Genk defeated Cork City 2-1 on the road in game two and finished off the Irish club 3-1 on aggregate.
At Mlada Boleslav, Czech Republic:
Despite a 1-0 game-two road setback, Shkendija still eliminated FK Mlada Boleslav 2-1 on aggregate.
Cheikou Kouyate scored twice (8',25') as West Ham United overcame their series-opening road defeat with a 3-0 home domination of NK Domzale and ousted the Slovenian club 4-2 on aggregate.
At Herning, Denmark:
Filip Novak scored the series-winning goal in the 104th minute as FC Midtjylland, after dropping a game-two 1-0 home regulation decision to Hungary's Videoton which deadlocked their series at 1-1 on aggregate, ousted their guests 2-1 on aggregate.
At Helsinki, Finland:
Mikael Boman (35') and Jakob Ankersen (82') each scored once as IFK Gothenburg recovered from their series-opening home defeat with a game-two 2-0 road blanking of HJK Helsinki and won their series 3-2 on aggregate.
At Ovidiu, Romania:
A 0-0 game-two road draw with Viitorui Constanta was more than good enough for KAA Gent as the Belgian club won their series 5-0 on aggregate.
At Nicosia, Cyprus:
After Apollon Limassol outscored visiting Grasshoppers 2-1 in regulation of game two to deadlock their series at 3-3 on aggregate, overtime goals from Caio Alves (103') and Nikola Gjorgjev (120'+1) enabled the Swiss club win their series 5-4 on aggregate.